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Mechanism of cell ERK harm

WARNING!  EMF radiation from this PC depletes your bioenergy! Get protection for your safety!


Your body has an energy signalling system that's vital for its proper function. See Energy Systems.  You need to protect it!
Don't exposure yourself to EMFs without protection. You wouldn't expose yourself to the sun for hours - you'd get skin cancer soon enough.  EMF is invisible and every day EMF stress affects your body putting your health at risk; a wide range of symptoms result. Just read What Doctors warn.  EMF radiation depletes bioenergy, compromising your immune system! There is a cumulative effect. Take advantage of my website to find out more about these modern day hazards.
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Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies

This study demonstrates for the first time a detailed molecular mechanism by which electromagnetic irradiation from mobile phones induces the activation of the ERK cascade and thereby induces transcription and other cellular processes.

Biochemical Journal  published  25 April 2007

Biochem. J. (2007) 405 (559–568)

Research Scientists: Joseph FRIEDMAN*, Sarah KRAUS*, Yirmi HAUPTMAN†, Yoni SCHIFF† and Rony SEGER*1

*Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel, and
†Gal Safe Ltd, Rishon Lezion, Israel 75153

The exposure to non-thermal microwave electromagnetic fields generated by mobile phones affects the expression of many proteins.  This effect on transcription and protein stability can be mediated by the MAPK (mitogen-activated protein kinase) cascades, which serve as central signalling pathways and govern essentially all stimulated cellular processes.  Indeed, long-term exposure of cells to mobile phone irradiation results in the activation of p38 as well as the ERK (extracellular-signal-regulated kinase) MAPKs.

In the present study, we have studied the immediate effect of irradiation on the MAPK cascades, and found that ERKs, but not stress-related MAPKs, are rapidly activated in response to various frequencies and intensities.  Using signalling inhibitors, we delineated the mechanism that is involved in this activation.  We found that the first step is mediated in the plasma membrane by NADH oxidase, which rapidly generates ROS (reactive oxygen species).  These ROS then directly stimulate MMPs (matrix metalloproteinases) and allow them to cleave and release Hb-EGF [heparin-binding EGF (epidermal growth factor)].

This secreted factor activates the EGF receptor, which in turn further activates the ERK cascade.  Thus this study demonstrates for the first time a detailed molecular mechanism by which electromagnetic irradiation from mobile phones induces the activation of the ERK cascade and thereby induces transcription and other cellular processes.
Abbreviations used:
DPI = diphenyleneiodonium;
EGF = epidermal growth factor;
EGFR = EGF receptor;
ERK = extracellular-signal-regulated kinase;
FCS = fetal calf serum;
GPCR = G-protein-coupled receptor;
Hb-EGF = heparin-binding EGF;
HSP = heat-shock protein;		 JNK = c-Jun N-terminal kinase;
MAPK= mitogen-activated protein kinase;
MEK = MAPK/ERK kinase;
MMP = matrix metalloproteinase;
NAC = N-acetylcysteine;
PI3K = phosphoinositide 3-kinase;
PKC = protein kinase C;
ROS = reactive oxygen species;
SAPK = stress-activated protein kinase.
1To whom correspondence should be addressed (email rony.seger@weizmann.ac.il).
Published as BJ Immediate Publication 25 April 2007, doi:10.1042/BJ20061653
PubMed citation 1: Biochem J. 2007 Aug 1;405(3):559-68.
 

Further research identifying real mechanisms by which cellular processes in cells of living beings can be affected by exposure to EMF radiation from cellphones, cordless phones and like devices that transmit at microwave frequencies.  It follows that utilising the available intervention technologies to provide protection is essential.

You have a sophisticated body electronics system that is vital to its function.  So don't allow yourself to be exposed to health risks invisibly imposed by EMF radiation from electric & magnetic fields and pulsed microwave transmission signals, which are at frequencies that disrupt your brain and cellular functions.  Cellphone and cordless phone use does carry well-established risks!  EMF stress occurs with all other electric and electronic devices, too.  There are adverse health effects - see What Doctors Warn.  Scientific studies have shown that EMF exposure has a cumulative effect, increasing over time.   Be sure to reduce the risks for your children who face a lifetime of exposure and those with poorer health conditions, they are especially at risk.  For an appreciation of this start at Child Risks.

Depletion of your body's bioenergy causes a lowered energetic capability, at a fundamental atomic level.  See Atoms & EMF.  Disturbance of it's inherent bioenergetic system results in disruptions to cellular functions and a compromised immune system.  Start at Energy Systems.  Quite simply, your body systems are no longer able to work in the way that they would if such destructive interference from EMR was not imposed on you.  To see how human energies are affected by common electronic devices see bioenergy test charts showing patterns typical of that experienced by everyone from Human Tests.

If you can't understand why the authorities are allowing you to be exposed to such risks, start at my Research page.  So-called "safety" regulations only consider thermal (tissue heating) effects, but frighteningly disregard low frequency biological effects. Strong vested interests resist change to this in spite of mounting evidence.  For your own health and safety, and sustainable wellness, you need to adopt the Precautionary Principle with some urgency to avoid the risks of the invisible hazard of EMR that do compromise your health.  You can now make use of the amazing new GIA Wellness protection available to reduce the effects of EMR, and have the chance to enjoy sustainable wellness.  See GIA Wellness Protection Products.

Find out more so you can immediately protect yourself and achieve optimal health in our increasingly electropolluted world.

GET  PROTECTION  to avoid  ADVERSE  HEALTH  EFFECTS  and the  CUMULATIVE EFFECTS.

Health and safety needs to be treated seriously.  Be sure to get GIA Wellness (formerly Biopro Technology) protection for others that you care about, too.  Tell others about my website and the wealth of information it provides so they can avail themselves of this and the amazing new Biopro protection against the adverse health risks of increasing exposure to EMF in our modern technological world.

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